It wasn't your typical Saturday afternoon bar crowd. Five hundred runners in their bedroom best made their way to Power Plant Live! for Cupid's Undie Run.
"If these people can get through their life suffering with NF, which is a very painful disease, we can go run a mile in our undies in the freezing cold," Race Organizer, Kate Gibson, said.
All of the runners participated to see an end to Neurofibromatosis, a genetic disorder that causes tumors to grow on nerves throughout the body.
Organizers say it is generally diagnosed in children.
"The tumors don't do anything except get in the way and they cause blindness, deafness, learning disabilities. They can lead to cancer and there's no known cure and right now one in 3,000 children are diagnosed with it. Which is more than cystic fibrosis, Huntingston's disease and muscular dystrophy combined," Gibson said.
"You're robbed of your childhood years spent in the hospital and i think it's a huge thing. I had a wonderful childhood and i want children that have these issues to have help and not have to deal with that," Colleen Vallar said.
It's first time in Baltimore, there were similar scenes in 30 other cities all around the world, with a goal of $3 million to help bring an end to NF.
The runners in Baltimore contributed about $52,000 towards that $3 million goal.
All of the money raised by the run goes directly to the Children’s Tumor Foundation.